【摘要】 目的 :探讨高龄手术病人 (6 0～ 80岁 )在充足营养底物支持下 ,应用重组人生长激素 (rhGH)能否减轻术后疲劳综合征 (POF)。　方法 :选择 4 0例接受胃大部切除术或其他手术创伤的高龄病人 ,随机分组进行双盲试验。两组病人术后给予相同标准的营养底物 ,rhGH组术后第 3天起给予rhGH 9U/d ,连续 7天。对照组给予安慰剂 ,监测病人术后疲劳度、氮平衡、转铁蛋白及体重。　结果 :于术后 7、14天rhGH组疲劳度 (Christensen评分 )低于对照组 (P <0 .0 5 ) ;排氮量明显低于对照组 (P <0 .0 0 1) ;转铁蛋白下降明显低于对照组 (P <0 .0 1) ;两组体重均有下降 ,相比无显著差异 (P >0 .0 5 )。　结论 :应用rhGH有利于减轻高龄手术病人术后POF。更多还原

【Abstract】 Objectives: The aim of this study was to define whether growth hormone therapy would reduce the course of postoperative fatigue (POF) in aged patients (60～80 years old) with nutritional support. Methods: Forty aged patients who underwent partial gastrectomy or other operations were randomized into two groups. All patients were treated with the same nutritional support formula.A group of patients was treated with rhGH for 7 day from the third day after operation, and control group treated with placebo.The score of POF, nitrogen balance, transferrin level and body weight were monitored. Results: Score of POF in rhGH group on day 7 and 14 after operation was lower than that in control group(P<0.05). Nitrogen excretion in rhGH group on day 7 and 14 after operation were lower significantly than that in control group(P<0.01). The level of transferrin was decreased in rhGH group at day 7 and 14 after operation,but significantly higher than that in control group.There was no significant difference between two groups in weight loss on day 7 and 14 after operation(P>0.05). Conclusions: Aged patients with rhGH after major operation can recover more rapidly from POF.更多还原