【摘要】 目的 :研究非小细胞肺癌的增殖活性及 P5 3的改变。方法 :应用免疫组化技术检测 5 2例肺癌的P5 3基因表达情况及其 PCNA阳性情况。免疫组化染色采用 S- P法。结果 :P5 3总阳性率为 5 1 .9% ,不同类型肺癌之间差异没有显著性 (χ2 =4 .4 87,P=0 .1 0 6 ) ;P5 3阳性组的增殖活性较 P5 3阴性组为高 ,差异有显著性 (Fisher’s exact test,P=0 .0 0 2 <0 .0 5 )。结论 :P5 3基因的变化与肺癌的增殖活性有关 ,其在肺癌的发生发展中具有重要作用更多还原

【Abstract】 Objective:To study the alteration of P53 in Non-small Cell Lung Cancer and the proliferation of this cancer. Methods:The immunohistochemical technique with S-P method was used to detect the expression of P53 and the positive stain of PCNA. Results:The total positive rate of P53 is 51.9% without statistical differences among the histological types(χ 2= 4.487, P = 0.106). The proliferation between p53 positive group and P53 negative group have statistical differences (Fisher’s exact test,P=0.002<0.05). Conclusions:The proliferation of lung cancer wasn’t related with the alteration and P16. They played important roles in the processing of lung cancer.更多还原