【摘要】 目的 :探讨肝移植患者术后早期死亡原因。方法 :回顾性分析 4 2例肝移植患者资料 ,通过比较术后早期死亡患者与生存患者术前肝功能、凝血状态、供肝冷热缺血时间及术中情况等资料 ,探讨导致术后早期死亡的相关因素。结果 :13例患者于术后早期死亡 ,其中 2例死于移植肝原发无功能 ,2例死于血管并发症 ,另外 9例术前肝功能及凝血功能明显较生存组差 ,术中出血量多于生存组 ,术中低血压时间、手术总时间、无肝期长于生存组。结论 :术前患者的肝功能 ,特别是凝血功能不良及由此导致的术中出血问题是术后早期死亡的主要原因 ,其次为血管并发症及移植肝原发无功能更多还原

【Abstract】 Objective:To investigate the correlated factors of early mortality after orthotopic liver transplantation. Methods:The preoperative liver function, coagulative status, the graft′s warm and cold ischemia times and the details of the operations of 42 patients were summarized retrospectively and the comparison between survival and death patients performed to analyse the correlated factors of early death after orthotopic liver transplantation. Results: Thirteen of the 42 patients died early after the transplantation. Two died of vascular complication and two of graft primary nonfunction. The comparison between those without identified causes (9 patients, in death group) and survivors ( 29 patients, in survival group) showed that the patients in death group had a poorer preoperative liver function and coagulative status than those in survival group, the blood loss was more than that in survival group, the length of time of operation, the duration of hypotension and anhepatic time were also longer than those in survival group. Conclusion: The poorer preoperative liver function, and especially the coagulative status were the main causes of early mortality after orthotopic liver transplantation, the vascular complications and the graft primary nonfunction were the other reasons that led to some patients’ deaths.更多还原