【摘要】 目的 :研究高脂血症痰瘀病理演变中胰岛素抵抗变化的特点。方法 :对高脂血症35例痰瘀阻络证、 33例脾虚痰凝证及 2 9例非痰非瘀证病人和 30例健康人进行了中医症征积分、血糖 (FPG)、血胰岛素 (FINS)、胰岛素敏感性指数 (ISI)、胰岛素分泌功能指数(IS)、血清脂质过氧化物 (LPO)和血清超氧化物歧化酶 (SOD)检测及相关分析。结果 :痰瘀阻络证和脾虚痰凝证病人的FPG、FINS、IS及LPO均呈健康对照组 <非痰非瘀证组 <脾虚痰凝证组 <痰瘀阻络证组的递进趋势 ;而ISI、SOD则相反 ,呈现递减的趋势 ;“痰凝”症征积分与FPG、ISI分别存在着相关关系 (均P <0 0 5或 <0 0 1) ,而“血瘀”症征积分与FINS、ISI等指标之间存在着相关关系 (均P <0 0 5或 <0 0 1) ,其中ISI异常及相关的程度均明显高于“痰凝”组。结论 :胰岛素抵抗对高脂血症“痰瘀病理”演变有一定的影响更多还原

【Abstract】 Objective: To study the characteristics of the change of insulin resistance in the pathological evolution in the phlegm-blood stasis syndrome of hyperlipemia. Methods: Among the hyperlipemia cases like syndrome of phlegm-blood stasis 35 cases, syndrome of phlegm congealment due to spleen-deficiency 33 cases, non-phlegm and non blood-stasis 29 cases and 30 healthy people, the related tests and analysis were made like the integral of tcm symptoms and syndromes, FPG, FINS, IS, LPO and SOD. Results: The contents of FPG, FINS, IS, LPO in hyperlipemia cases were in the following sequence: healthy control group < non-phlegm non blood-stasis group< phlegm congealment due to spleen-deficiency syndrome group< phlegm-blood stasis syndrome group; while the results of the contents of ISI and SOD were vice versa and had a declining tendency; the integral of ’phlegm congealment’ had correlative relations with the contents of FPG and ISI ( P <0.05 or <0.01), while the integral of ’ blood-stasis’ had correlative relations with the contents of FINS and ISI ( P <0.05 or <0.01). The abnormality and correlative degree of ’blood-stasis’ were higher than that of the ’phlegm congealment’ group. Conclusion: Insulin resistance has certain effects on pathological evolution of hyperlipemia with phlegm and blood-stasis syndrome.更多还原