【摘要】 目的 :研究通痹灵、雷公藤多甙及青藤碱对Ⅱ型胶原蛋白诱导性大鼠关节炎模型(CIA)滑膜组织病理的影响。方法 :滑膜组织常规脱水、包埋、制片、HE染色 ,观察炎性细胞浸润、纤维组织增生、滑膜细胞增生及巨噬样A型细胞增生情况。结果 :通痹灵组CIA大鼠滑膜组织的炎性细胞浸润、纤维组织增生和巨噬样A型细胞明显受抑制。四种细胞病理改变的总积分与造模组比较有非常显著的差异。结论 :通痹灵治疗类风湿性关节炎的机理可能与抑制炎性细胞浸润、纤维组织增生和巨噬样A型细胞增生有关。更多还原

【Abstract】 Objective: To study the effect of Tongbiling and Tripterygium wifordii hook and sinomenine on pathology of synovial tissue in experimental arthritis rats. Methods: The inflammatory cell infiltration and fibroblast hyperplasia and synovial cell hyperplasia and macrophagia-like type A cell hyperplasia were assayed after synovial membrane was managed on pathological routine. Results: Tongbiling could inhibit inflammatory cell infiltration and fibroblast hyperplasia and macrophagia-like type A synovial cell hyperplasia of synovial membrane in experimental arthritis rats. Conclusion: The mechanism of curative effect of Tongbiling on arthritis concern with inhibiting the inflammatory cell infiltration and fibroblast hyperplasia and macrophagia-like type A synovial cell hyperplasia of synovial membrane.更多还原