【摘要】 目的 :探讨 GM- CSF受体 α亚单位表达在急性白血病中的意义。方法 :采用流式细胞技术检测 4 7例初诊急性白血病患者 GM- CSF受体 α亚单位表达 ,同时采用生化法测定血清 L DH和HBDH,并于标准化疗第 1疗程结束时计算 MBDI。结果 :AML 患者 GM- CSF受体 α亚单位表达明显高于 AL L 患者 ;GM- CSF受体 α亚单位的较高表达主要见于 AML- M5和 AML- M0 患者 ,AL L 患者呈阴性表达 ;GM- CSF受体 α亚单位的表达水平在血清 L DH/ HBDH升高组与正常组两组间、在 MB-DI≥ 5 0 %与 <5 0 %两组间无显著性差异。结论 :急性白血病 GM- CSF受体 α亚单位表达测定对于AML 尤其是 AML- M5和 AML- M0 的诊断与鉴别诊断有帮助 ;GM- CSF受体 α亚单位表达水平似乎与白血病细胞肿瘤负荷和化疗近期疗效无关更多还原

【Abstract】 Objective:To evaluate the clinical significance of GM- CSF receptorα subunit ex- pression in patients with acute leukemia.Methods:In 4 7patients with de novo diagnosed acute leukemia,GM- CSF receptorα expression was assayed by direct imm unofluorescence method,serum activity of L DH and HBDH was m easured with biochem ical m ethod,bone m arrow blastdecrease index (MBDI) was calculated on the tim e when the first two rounds of standard induction regim en were com pleted.Results:GM- CSF receptorα expression was obviously higher in AML - M5and AML - M0subtype(P<0 .0 5 ) ,and in those AML patients with myeloid differentiation antigen overexpression. There wasn’t significant difference of GM- CSF receptorα expression in two groups between the AML patients with increased and normal L DH (or HBDH ) activity,or two groups with MBDI more and less than 5 0 % (P<0 .0 5 ) .Conclusion:GM- CSF receptorα examination m ight be useful to the diagnosis of AML especially M5and M0 subvariety.m oreover,GM- CSF receptorα expression was not associated with leukemic cell load and therapeutic outcom e in the first two rouds of induction thera- py.更多还原