【摘要】 目的　比较吡喹酮、丙硫咪唑单独和两药合用治疗脑实质型脑囊虫病的临床疗效。方法　 90例入选病例随机分三组 ,完成治疗剂量后 3个月复诊 ,从头痛、癫痫发作等症状缓解程度及头颅MRI病灶改善情况两方面来判断及评价三组治疗方案的疗效。结果　①联合用药组在缓解头痛、控制癫痫方面效果明显优于单独用药组(P <0 .0 5 ) ,在头颅MRI病灶改善方面有非常显著性差异 (P <0 .0 1) ;②药物不良反应三组间无明显差异。结论　对于脑实质型脑囊虫病不伴颅内压升高者 ,吡喹酮与丙硫咪唑合用疗效明显提高更多还原

【Abstract】 Objective To evaluate the efficacy of separate and combined use of praziquantel and albendazole.Methods Ninety patients with parenchymal neurocysticercosis were randomly allocated in three groups:group 1 using praziquantel,group 2 using albendazole and group 3 using praziquantel together with albendazole.The evaluation of curative effect is on the basis of reducing cystic lesion number on MRI,headache amelioration and epilepsy improvement before treatment and three months after treatment.Results ①Combined use of praziquantel and albendaxole(group 3) is more effective in ameliorating headache,improving epilepsy than the use of praziquantel and albendazole respectively (group 1,2) ( P <0.05) and in resolving lesions number on MRI ( P <0.01).②There is no differences if the side effects reported by objects in three groups.Conclusions Combined use of praziquantel and albendazole greatly improves the therapy of parenchymal neurocysticercosis with no obvious intracranial hypertension and shortens the treating time.更多还原