【摘要】 检测血清Ⅲ型前胶原 (PCⅢ )、层粘连蛋白 (LN)和透明质酸 (HA)的水平与研究其对高血压心肌纤维化患者的临床价值。高血压左心室肥大组 35例、高血压不伴左心室肥大组 30例及对照组 4 0名 ,用超声心动图测定左心室重量指数 (LVMI) ,用酶联免疫吸附分析法 (ELISA)测定血清PCⅢ、LN和HA。高血压左心室肥大组较高血压不伴左心室肥大组和对照组的血清PCⅢ、LN和HA含量明显增高 (P <0 .0 1 )。结论是血清PCⅢ、LN和HA可以作为高血压左心室肥大患者心肌纤维化的观察指标更多还原

【Abstract】 To investigate the value of serum hyaluronic acid(HA), laminin(LN) and type Ⅲ procollagen (PCⅢ) levels in essential hypertensive patients on myofibrosis cordis, two dimensional echocardiography was performed to determine left ventricular mass index(LVMI).Serum PCⅢ, LN and HA were measured by ELISA for blood samples from 35 essential hypertensive patients with left ventricular hypertrophy(LVH), 30 essential hypertensive patients without LVH and 40 healthy subjects.Serum PCⅢ LN and HA were significantly increased( P <0.01) in the hypertensive patients with LVH as compared with those without LVH and heaethy subjects. The results suggest that PCⅢ, LN and HA may act as serum markers for myofibrosis cordis in the hypertensive patients with LVH.更多还原