【摘要】 目的　探讨 2SHRZ及 2S3 H3 R3 Z3 两组化疗方案在抗肺结核强化期治疗中对肝功能的影响情况。方法　抽取 2 0 0 0年至 2 0 0 2年在本院就诊的乙型病毒性肝炎表面抗原 (HBsAg)阴性的肺结核患者 191例 ,其中2SHRZ组及 2S3 H3 R3 Z3 组分别为 87例和 10 4例 ,观察其两个月治疗期间患者肝功能的情况并进行对比分析。结果　 2SHRZ组及 2S3 H3 R3 Z3 组治疗后出现肝功能异常者分别为 9例和 13例 ,轻度血清谷丙转氨酶 (ALT)升高患者 (4 0～ 10 0U/L)分别为 6例和 11例 ;而中重度ALT升高者 (≥ 10 0U/L)分别为 3例和 2例 ;两组间各项指标对比差异均无显著性 (P >0 .0 5 )。结论　在无其它不良因素影响下 ,2S3 H3 R3 Z3 治疗后引起的肝功能损害的机会及程度与 2SHRZ相当 ,肝损发生率皆不高 ,以轻度肝细胞损伤为主 ;2S3 H3 R3 Z3 方案既安全、疗效肯定、服用方便、经济 ,值得在抗肺结核强化期治疗中推广使用更多还原

【Abstract】 Objective In order to understand influence of 2SHRZ and 2S 3 H 3 R 3 Z 3 TB treatment schemes on liver function. Methods 191 TB cases with HBsAg negative in 2000～2002 were divided to two groups and treated with 2SHRZ and 2S 3 H 3 R 3 Z 3 respectively . Their liver function (ALT) was observed in 2 months of treatment and analyzed. In 2SHRZ treatment group (87 cases), liver function of 9 cases became abnormal after treatment. Results In 2S 3 H 3 R 3 Z 3. treatment group (104 cases), liver function of 13 cases became abnormal. There were 6 cases and 11 cases with ALT 40～100U/L in the two groups respectively. There were 3 cases and 2 cases with ALT above 100U/L in the two groups respectively. There was no significant difference between the two groups. Conclusions Without other harmful factors, influence of 2SHRZ and 2S 3 H 3 R 3 Z 3 TB treatment scheme on liver function was similar. The rate of liver lesion was not high using the two treatment schemes and most of them had only mild liver cell lesion. 2S 3 H 3 R 3 Z 3 treatment scheme was not only safe but also convenient, economical and should be popularized in TB treatment.更多还原