【摘要】 目的:为研究内环境紊乱与急性脑血管病(acutecerebralvasculardisease,ACVD)死亡之间的关系。方法:采用回顾性定群研究的方法,分析了423例ACVD患者入院时血浆渗透压与死亡之间的关系。结果:死亡组入院时血浆渗透压较成活组明显增高,用Logistic回归分析方法在排除了年龄、性别、脑血管病类型、疾病严重程度、血糖、糖尿病史等因素影响后,发现血浆渗透压增高是决定急性期死亡的一个独立的直接危险因素。影响血浆渗透压的因素较多,其中血钠、血糖、血尿素氮及年龄与渗透压高低密切相关,公式计算所得结果与实验室数据吻合性差。结论:在临床工作中为改善病人预后,应注意水电解质平衡,以实验室数据为依据,参考血液生化指标及临床,及时纠正患者增高的渗透压。更多还原

【Abstract】 Objective In order to ex plore the effects of abnormal physiological parameters on t he death after strok e.Methods The association of raised plasma osm olality measured at admission on death after stroke was studied by means of retrospective cohernt analysis.Resu lts423patients were included.Mean adm ission plasma osmolality were sig-nif icantly higher in those who died c ompared with survivors.Raised admi ssion pla sma osmolality was directly associ-ated with mortality independentof age,sex, stroke subtype,stroke seve rity,blood glucose,diabetes mellitus.There are ma ny effects to influence the pla sma osmolality ,especially serum so dium,potas sium,glucose,urea.Agreement between measured plasma osmolality and calculate d plasma osmolality wa s poor.Conclusions In clinical practice we must pay att ention to water homeosta sis and correct timely plasma osmola lity imbalance acc ording to measure d plasma osmolality and blood biochemistry.更多还原