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注射用头孢吡肟与二羟丙茶碱注射液在4种输液中配伍后的稳定性
The stability after compatibility of cefepime and diprophylline in different kinds of intravenous infusions
【摘要】 目的:考察室温下6h内注射用头孢吡肟与二羟丙茶碱注射液在4种输液中配伍后的稳定性。方法:采用双波长和一阶导数分光光度法测定各配伍液中头孢吡肟和二羟丙茶碱的含量变化情况。结果:室温下注射用头孢吡肟或二羟丙茶碱注射液单独与4种输液配伍后6h基本保持稳定;头孢吡肟与二羟丙茶碱注射液配伍后,室温下二羟丙茶碱在4种输液中6h基本无降解,而头孢吡肟降解1%左右。结论:注射用头孢吡肟与二羟丙茶碱注射液配伍后在4种输液中6h内保持基本稳定。
【Abstract】 OBJECTIVE:To inspect the stability after compatibility of cefepime and diprophylline in four kinds of infusions in6 hours in room temperature.METHOD:To test the contents of cefepime and diprophylline in all kinds of infusions using double-wavelength and first order derivative spectrophotometry.RESULTS:The contents of cefepime and diprophylline kept stability in 6 hours after they admixture with the four kinds of infusions alone.After the compatibility of cefepime and diprophylline in the four kinds of infusions,The contents of diprophylline degraded little,and that of cefepime degraded for about 1%.CONCLUSION:After the compatibility of cefepime and diprophylline in the four kinds of infusions,they kept relatively stability.
【Key words】 cefepime; diprophylline; compatibility; stability; double-wavelength spectrophotometry; first order derivative spectrophotometry;
- 【文献出处】 中国现代应用药学 ,Chinese Journal of Modern Applied Pharmacy , 编辑部邮箱 ,2002年S1期
- 【分类号】R942
- 【下载频次】68