【摘要】 目的:研究丹参、金钱草单用或与环孢素 A(CsA)、硫唑嘌呤(Aza)、泼尼松(Pred)三联免疫抑制药物合用对异种心脏移植超急性排斥反应的作用。方法:选用豚鼠—大鼠异种心脏移植模型,分别观测 B 组(单纯豚鼠—大鼠心脏移植,对照组)、C 组(CsA、Aza、Pred 治疗组)、D 组(丹参联合 CsA、Aza、Pred 治疗组);E 组(金钱草联合 CsA、Aza、Pred 治疗组)、F组(丹参治疗组)及 G 组(金钱草治疗组)移植心脏存活时间。结果:各实验组移植心脏存活时间分别为14.7±5.6、13.6±4.9、24.5±4.4、15.4±6.4、25.8±4.1及14.3±4.1min。结论:与金钱草治疗组及 CsA、Aza、Pred 治疗组比较,丹参能够延长异种移植心脏存活时间(P<0.05),但不能阻断超急性排斥反应的发生,丹参可能对大鼠补体有抑制或清除作用。丹参、金钱草分别与 CsA、Aza、Pred 合用无抑制协同作用。更多还原

【Abstract】 Objective:To study the inhibitory effects of Radix Salviae Militorrhizae(SM)and Herha Lysimachiae(HL)on car- diac xenograft rejection.Methods:The cardiac xenograft model of guinea-pigs and rats were divided into 6 groups includ- ing group B(cardiac xenografting),group C(CsA,Aza,Pred.treatment),group D(SM combination with CsA,Aza and Pred.),group E(HL combination with CsA,Aza and Pred.),group F(SM singly),and group G(HL singly),to demonstrate their inhibitory effects.The survival time of the transplanted hearts was determined by measuring the beating time of transplanted guinea-pig hearts.Results:The survival time(min) of group B,C,D,E,F,G were 14.7±5.62,13. 6±4.92,24.5±4.43,15.4±6.35,25.8±4.12 and 14.3±4.12 respectively.Conclusions:Immunosuppression with SM singly,or in combination with CsA,Aza,and Pred.before grafting was effective in prolonging xenograft survival time,but failed to prevent the hyperacute rejection;immunosuppression with HL singly,or in combination with CsA, Aza and pred.before grafting was not effective in prolonging xenografe survival time.更多还原