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西洋参茎叶皂甙及单体F11抗缺氧作用的研究
Antianoxic Effects of Panax quinguefolium Saponin and F11
【摘要】 西洋参茎叶皂甙及单体F11连续灌胃5天,对小鼠断头致急性缺氧、双侧结扎颈总动脉致缺血造成的缺氧、NaNO2、KCN致化学性缺氧等均有明显的保护作用,并能显著抑制缺氧小鼠脑过氧化脂质含量的升高。
【Abstract】 ? Panax quinquefolium saponin(PQS) and F11 administrated orally for 5 days had the markedly protective effects on the anoxia in mice induced by decapitation,the occlusion of the bilateral carotid arteries,the chemical anoxia caused by NaNO2 (800mg/kg,sc) and KCN(4.5mg/kg,ip).In addition,PQS and F11 significantly inhibited the formation of lipid peroxide in brain tissue of hypoxia mice induced by KCN (4.5mg/kg,ip).
- 【文献出处】 中药药理与临床 ,PHARMACOLOGY AND CLINICS OF CHINESE MATERIA MEDICA , 编辑部邮箱 ,1998年04期
- 【分类号】R285.5
- 【被引频次】19
- 【下载频次】133