【摘要】 目的研究实验性皮肤癌基底膜的变化。方法用甲基胆蒽诱发的Balb／c小鼠，对其癌组织基底膜的层粘蛋白进行免疫组化染色。结果在皮肤不典型增生，皮肤乳头状瘤和原位癌，基底膜呈完整的线性分布，随着肿瘤分化程度的降低，基底膜的线性分布出现不连续缺损，甚至基本消失。结论基底膜的分布状态与肿瘤组织的分化程度有密切关系。更多还原

【Abstract】 The author studied the changes of basement membrane (BM) of experimental skin cancerin mouse. Methods Using Balb/c mouse skin lesions induced by 20-mehtylcholenthrene. laminin ofbasement membrane was stained by immunohistochemislry. Results A distinct and continous BM was showedin normal, dysplasic epithelium and carcinoma in situ. Depending on the level of cancer cell differentiation, BMof invasive carcinoma might be discontinous, fragmental or completely absent. Conclusions A distinct andcontinous BM is associated with differetiation of tumor tissue.更多还原