【摘要】 采用3种剂量的柴胡桂枝汤（5g／kg，10g／kg，20g／kg）灌胃，观察其对利血平腹腔注射诱发的大鼠实验性胃溃疡的胃粘膜保护作用，并与病理组及正常组对照。结果表明3种剂量的柴胡桂枝汤均使大鼠溃疡指数降低（P＜0．05）；其对大鼠胃粘膜的生长抑素（SS）无明显影响；而中剂量的柴胡桂枝汤能显著抑制胃粘膜胃泌素（GAS）的分泌（P＜0．05）。提示中剂量柴胡桂枝汤抑制胃粘膜GAS的释放，减少胃酸分泌对胃粘膜的损害作用，可能是预防大鼠利血平胃溃疡形成的主要作用机制之一。更多还原

【Abstract】 The protective effect of chaihuguizhi (CHGZ)decoction on the model group of gastriculcer caused by reserpine was observed with different doses of CHGZ. These results showed thal allthree different doses of CHGZ could significantly lower UI of gastric mucosa of rats,compared withthe model group(P＜0．　05). Each dose of CHGZ decoction has no distinct effect on SS in gastric mu-cosa(P ＜0. 05). However,CHGZ at a dose of 10 g/kg can remarkably lower contents of GAS(P ＜0. 05 ). It suggested that CHGZ decocti0n (10 g/kg)can remarkably lower the contents of GAS in gas-tric mucosa. This is one of the main mechanisms that CHGZ can treat peptic ulcer and prevent relapseof peptic ulcer.更多还原