【摘要】 用不同浓度的柠檬酸铝、混合稀土及亚硒酸钠溶液浸泡温石棉１小时后，再将其与人胚肺（ＨＥＬ）细胞共同孵育，测定培养液中的过氧化氢（Ｈ２Ｏ２）含量。结果显示，未经处理的温石棉可诱导ＨＥＬ细胞产生Ｈ２Ｏ２，并呈明显的剂量反应关系。与未处理温石棉组相比，经３种化合物预处理的温石棉所致ＨＥＬ细胞产生的Ｈ２Ｏ２量明显降低，其抑制率随化合物浓度的增加而增高，呈一定的剂量依赖性。结果表明，用３种化合物预处理温石棉，均可抑制其诱导ＨＥＬ细胞产生Ｈ２Ｏ２。更多还原

【Abstract】 After being soaked in aeuminium citrate,mixed rare earths or sodium selenite solutions at different concentrations for 1 hour,chysotile were incubated with human embryo lung cells(HEL)cells.Then,the hydrogen peroxide(H 2O 2) in the culture medium were determined.The results showed that the native chrysotile caused dosedependent increases of H 2O 2 in the culture medium (r=0 039P<0 05),but the three compoundspretreated chrysotile induced less H 2O 2 production than the native chrysotile.These results indicated that the pretreatment of chrysotile with three compounds can inhibite the chysotileinduced H 2O 2 production in HEL cells.更多还原