【摘要】 用自动吸入烹调油烟（ＣＯＦ）的染毒方法研究各剂量组ＣＯＦ对昆明种小鼠骨髓细胞和睾丸初级精母细胞畸变率、骨髓细胞染色体畸变率的影响。结果显示：吸入ＣＯＦ的各剂量组小鼠骨髓细胞和睾丸初级精母细胞畸变率明显增高，中、高剂量与阴性对照组相比差异显著，而且呈剂量反应关系。表明ＣＯＦ进入体内后，既具有体细胞诱变性，也能透过血睾屏障，具有生殖细胞的诱变性。更多还原

【Abstract】 Study effects on chomosome aberration rate in bone marrow cell and testic spermatogonial cell in mice of toxicokinatics of inhalation exposure to cooking oil fumes.The results showed that COF could induce remarkable increase of chromosome aberration rate at dose respetively with significant difference(P<005) when compared with negative controls.A doseeffect relationship clearly existed.Thus,COF could induce an increase of chromosome aberration frequencies and was mutagenic activity on bone marrow cell and spermatognial cell COF in mice exposured to and could be transported through blood textis barris.更多还原