【摘要】 １日龄父母代罗曼（Ｌｏｈｍａｎｎ）蛋鸡１２０只，随机分为３组，分别喂以低锰（基础日粮含锰１３．６２ｍｇ／ｋｇ）、低锰高磷（基础日粮＋０．５％的磷）、补锰对照（基础日粮＋锰８０ｍｇ／ｋｇ）日粮。试验期８周。饲喂５～８周发病。低锰组发病率２６％，低锰高磷组２８％，补锰对照组无一发病。第４周时，体重分别为（２６７．９±８．３２）、（２１４．２±１０．４２）、（２６５．０±１２．１８）ｇ，低锰组、补锰对照组与低锰高磷组之间差异极显著（Ｐ＜０．０１）。肝锰含量分别为（５．４０±０．７４）、（２．８２±０．３６）、（８．４８±０．９６）ｍｇ／ｋｇ，补锰对照组与低锰组差异显著（Ｐ＜０．０５），与低锰高磷组差异极显著（Ｐ＜０．０１）。发病症状：精神沉郁，不愿走动，伏卧，跛行，单腿发病病腿向外侧伸展，双腿发病则内收呈“Ｏ”字形或外展呈“八”字形。剖检跗关节肿大，胫骨髁骨骨质增生、肿大，髁间沟变平坦。组织学检查，胫骨骺生长板增殖区变窄，软骨基质中粘多糖减少。超微结构变化，心肌纤维、肝细胞、胫骨骺生长板软骨细胞、睾丸精原细胞等线粒体肿胀与空泡化。更多还原

【Abstract】 One hundred and twenty 1 day old Lohmann egg laying chickens were randomly divided into 3 groups. Group I was fed with naturally Mn deficient diet (ND) of containing Mn 13.62 mg/kg, group2 with ND+phosphorus 0.4%, group3 with ND+Mn80 mg/kg. and the experiment lasted for 8 weeks. The chickens appeared clinical signs of Mn deficiency on 5th week to 8th week. The affected chickens showed ataxia and Lameness, and assumed a pasture of “O” or “X” shape when both legs affected. The enlargement and malformation of tibiometatarsal joint were found in post mortem examination with the condyles of tibia proliferated and enlarged and the intercondylar fossa flattened. Pathohistological lesions showed that the mucopolysaccharide reduced in extracellular matrix of the proliferative zone of epiphyseal growth plate. Ultrastructural changes showed that the mitochondria in liver cells, cardiac muscle fibers, cartilage cells of tibia, spermatogonia appeared swollen and vacuolated with the disintegration and lysis of cristae. Rough endoplasmic reticulum dilated and ruptured. Golgi complex atrophied. The Mn level in liver of the Mn deficienct groups were significantly different from the Mn adding group(P<0.05 or P<0.01).更多还原