节点文献
桂枝汤有效部位A对体温的双向调节作用及其机理研究——对大鼠下丘脑PGE2含量的影响
Effect and Mechanism of Active Fraction A of Guizhi Decoctionon Dualdirectional Thermoregulation——Effect on Prostaglandin E2 in Hypothalamus of Rats
【摘要】 在酵母诱导的发热大鼠中，桂枝汤有效部位Ａ可使下丘脑前列腺素Ｅ２（ＰＧＥ２）水平下降；在安痛定诱导的低体温大鼠，则使ＰＧＥ２水平升高。
【Abstract】 The active fraction A (Fr. A) isolated from Guizhi decoction, which was orally administered, might cut down the rise of body temperature induced by yeast. The Fr.A also went up the hypothermy induced by aminopyrine intravenously. It lowered the content of PGE2 in febrile rats and raised the content in hypothemic rats in hypothalamus. The results indicate that Fr.A may regulate body temperature in dualdirection by means of promoting or inhibiting the metabolism of PGE2, a febrile medium in centre.
【关键词】 桂枝汤有效部位A；
体温双向调节；
前列腺素E2；
【Key words】 active fraction A of Guizhi decoction； dualdirectional thermoregulation； prostaglandin E2；
【Key words】 active fraction A of Guizhi decoction； dualdirectional thermoregulation； prostaglandin E2；
【基金】 国家自然科学基金
- 【文献出处】 中国实验方剂学杂志 ,CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE , 编辑部邮箱 ,1998年02期
- 【分类号】R285.5
- 【被引频次】38
- 【下载频次】180