【摘要】 为研究真皮替代鞘内屈肌腱的可行性,用兔真皮条移植替代鞘内屈趾肌腱,以正常鞘内屈趾肌腱为对照,观察移植物的形态及组织学变化、新生血管情况及生物力学性能。结果显示移植物术后24周时大体形态、新生血管及胶原排列与对照组近似,生理需要强度与对照组比较无显著性差异(P>0.05),毛囊及皮脂腺完全退化,移植物10周后延伸率为23%。实验表明真皮能替代鞘内屈肌腱。更多还原

【Abstract】 Objective:To explore the possibility of dermis grafts as the replacement of flexor tendons. Methods:Dermis grafts were used as the replacement of flexor tendons in rabbits.The intact normal flexor tendons were used for control.The dermis grafts were observed in morphology,histology,the new blood vessels and the ultrastructure,and were measured with Instron-1011 Tester.Results:At the end of 24 weeks after the replacement procedure,the appearance and shapes of grafts and the new blood vessels and the arrangments of collagen-fibril bundles in grafts were similar to the controls and the maximum stress and the maximum strain in the"toe region"of the grafts were close to those of controls(P>0.05).the hair follicles and the sebaceous glands in the grafts were degenerated completely by the end of 24 weeks postoperatively.Conclusion:The flexor tendons could be replaced by dermis grafts.更多还原