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尿中Bromantane代谢物的研究与GC/MS测定
Study on Bromantane Metabolites by GC/MS
【摘要】 采用GC/MS分析技术对一种新的免疫刺激剂Bromantane检出3种单羟基代谢物,并用SIM方式测定了代谢物在人尿中的排泄趋势。
【Abstract】 The metabolism of bromantane [N-(adarnant-2-yl) -4-bromoanilin.] and excretion dynamics of the metabolites have been investigated. Three kinds of monohydroxylated metabolites in urine after administration of single dose of the drug were found. It is established that during metabolism the hydroxylation takes place, the hydroxy group is added to the adamantan ring.
- 【文献出处】 质谱学报 ,JOURNAL OF CHINESE MASS SPECTROMETRY SOCIETY , 编辑部邮箱 ,1998年01期
- 【分类号】O657.6
- 【被引频次】3
- 【下载频次】30