【摘要】 本文用计算机图像分析仪对73例食管鳞状上皮非典型增生的细胞核进行形态计量测量，检测了胞核面积、周长、形态因子、异形指数、园球等5个指标，并与正常组相对照，结果表明，传统的组织学分级与形态定量分级基本一致，有其客观性。同时发现组织学诊断与形态计量诊断间有一些病例交叉，即下级病变的测量指标高于上级病变均值或上级病变的测量指标低于下级病变均值的情况。如果具体到某一病人，多指标形态定量可能比组织学诊断更准确，更能代表病变的现状。本文从食管鳞癌发生学的角度，对组织学诊断、细胞学诊断及形态定量诊断相互之间的关系及意义作了深入的分析，认为对食管非典型增生细胞核进行多指标形态分析，可为临床诊疗及估计预后提供帮助。更多还原

【Abstract】 In this paper, dysplasic squamous nuclei in esophagus in 73 patients were determined by computer image analyzer. Areas, perimeters, form factors, heterotypic indices and apherical degrees were examined and compared with normal control group.Results showed that traditional histological grading coordinate with morphological quantitative grading. For some patients, the histological diagnosis were inconsistent to morphologic diagnosis; the indices of lower level lesion were more than that of highers or indeices of higher level lesion less than that of lowers. For a specific patient, quantitative examination of multiple morphological indices might be more accurate than merely histological diagnosis. In this paper, the interconnection among histological diagnosis, cytological diagnosis and morphological diagnosis were studied, drew the conclusion that the determination of multiple morphological indices in dysplasic squamous nucleus may be help for clinical diagnosis, treament and prognosis.更多还原