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肾癌细胞Ki—67免疫组化染色指数与预后的关系

Prognostic value of Ki-67 Labeling Index in Renal Cell Carcinoma

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【作者】 吴伟成赵一鸣

【Author】 Wu Weicheng,et al(Department of Urology, 3rd Hospital of Beijing Medical University,Beijing 100083)

【机构】 北京医科大学第三医院泌尿外科!100083北京医科大学第三医院中心实验室

【摘要】 为探索肾癌预后较好的估价指标,41例肾癌根治标本Ki—67免疫组化染色。复发组的Ki—67染色指数显著高于未复发组(P<O.001)。多因素分析对肾癌预后有关的因素依次为Ki—67染色指数(P=0.005,相对重要性:100),肿瘤大小(P=0.007,相对重要性:44.7),分期(P=0.018,相对重要性:36.98)和年龄(P=0.023)。Ki—67染色指数估价复发的准确率为90.2%。研究结果表明Ki—67对肾癌预后的估价远优于常规的临床和病理指标,并能很好地预测肾癌的复发。

【Abstract】 Ki-67 immunostaining was performed on 41 renal cell carcinoma (RCC) sections todetermine its prognostic significance. Ki-67 labeling index of those who developed tumor recurrence was significantly higher than that of recurrence-free cases (P<0.001).In the multivariate analysis, Ki-67 labeling index (P=0.005, relative importance:100)was the most important factor affecting recurrence comparing with size(P=0.007,relative importance: 44.74), stage (P=0.018, relative importance: 36.98) and age (P=0.023). The correct rate of Ki-67 index in predicting the recurrence reaches to 90.2%.The results show that the Ki-67 labeling index is a very good,independent,prognosticmarker for RCC.

【关键词】 肾癌预后Ki—67免疫组化
【Key words】 Renal cell carcinomaPrognosisKi-67immunohistochemistry
  • 【文献出处】 肿瘤防治研究 ,CANCER RESEARCH ON PREVENTION AND TREATMENT , 编辑部邮箱 ,1998年03期
  • 【分类号】R737.11
  • 【被引频次】6
  • 【下载频次】233
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