【摘要】 目的：进一步阐明躯体传入冲动抑制中枢性升压反应的中枢递质机制。方法：用氯醛糖-脲酯混合麻醉、切断迷走神经的健康雄性家兔，侧脑室注射印防己毒（Picrotoxin）或中脑中央灰质（PAG）微量注射印防己毒，观察腓深神经（DPN）抑制电刺激下丘脑背内侧核（DMH）引起的中枢性升压反应的改变。结果：注药后DPN对DMH兴奋引起的升压反应的抑制作用削弱。结论：γ-氨基丁酸（GABA）受体参与了DPN抑制DMH兴奋诱发的升压反应，PAG是GABA受体在刺激DPN抑制DMH兴奋诱发的升压反应作用中的一个重要位点所在区。更多还原

【Abstract】 ObjectiveTo analyse the central transmitter mechanism that somatic afferent inputs inhibit thepressor response elicited by stimulation of dorsomedial hypothalamic nucleus(DMH). Methods: GABA receptorblocker-picrotoxin (200μl/ 0. 1 ml /1 min ) was injected into fateral ventricle of .brain or microinject pierotoxin (1μg/μl/1 min× 4) into periaquaductal grey(PAG) of male vagotomized rabbits under chloralose-urethan anesthesia. Results:The inhibitory effect of deep peroneal nerve(DPN) impulse on the pressor response to DMH stimulation was decreased (P<0. 05). Conclusion: GABA receptor in involved in the inhibitory effect of DPN on theabove central pressor response and midbrain PAG is one of the GABA receptor sites involved in the inhibitory effect.更多还原