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一种RNA病毒对人体大肠癌细胞超微结构的影响

Ultrastructural effect of a RNA virus on cells of human colonic carcinoma. Journal of Zhejiang Agricultural University

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【作者】 徐敏源俞少勇陈彤许沈华钱丽娟

【Author】 Xu Mingyuan; Yu Shaoyong; Chen Tong; Xu Shenhua; Qian Lijuan (Zhejiang Acadamy of Medical Sciences, Hangzhou 310013, China)

【机构】 浙江省医学科学院

【摘要】 通过对100例人大肠癌细胞超微结构的观察,研究了癌细胞内一种直径约为30nm的RNA病毒颗粒对癌细胞结构的影响。结果表明:病毒颗粒大部分分布在胞浆中,只有少数颗粒聚集在线粒体内或被溶酶体吞噬;癌细胞内存在另一种直径为150~500nm的特异性颗粒,开始是一种高电子密度的均质体,然后其结构逐步发生变化,最后整个颗粒内部形成很多与RNA病毒颗粒大小相似的小颗粒而释放到胞浆中,只留下一个明显的大颗粒外壳。

【Abstract】 This paper reports the ultrastructural effect of a RNA virus in diameter of 30 nm on human colonic carcinoma cells through observation of cancer cells ultrastructure of 100 cases. The results were as follows: The RNA virus particles were scattered all over in cytoplasm of cancer cells; A small number of RNA viurs particles gathered in mitochrondria and the RNA virus particles releaed from mitochrondria to cytoplasm when the mitochrondria “empty”. The RNA virus and other alarge particles were phagcytized lysosome to form secondary lysosome; The special large particles in diameter of 150 ̄500 nm were observed and there was a high electronic density substance in the initial stage. Their internal structure were changed step by step and formed small particles as RNA virus as. Lastly, the small particles were released from large particles to cytoplasm and the large particles became “empty”.

【基金】 国家自然科学基金,浙江省分析测试基金
  • 【文献出处】 浙江农业大学学报 ,Journal of Zhejiang Agricultural University , 编辑部邮箱 ,1998年S1期
  • 【分类号】R735.34
  • 【下载频次】18
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