【摘要】 应用免疫组织化学PAP法及多种单克隆抗体,对12例常见消化系统恶性肿瘤进行了原位研究。结果显示:①TIL在肿瘤局部主要分布于癌间质区,而癌实质区仅有极少数TIL浸润;②TIL中的主导细胞为CD₃⁺T细胞,且无论在实质区还是在间质区CD₄⁺细胞均少于CD₈⁺,癌间质区CD₄⁺/CD₈⁺比值大于癌实质区;③无论在癌实质区还是在癌间质区,均有部分CD₂₅⁺或HLA-DR⁺TIL存在,对于这些变化的内在机制文中也作了探讨。更多还原

【Abstract】 Employing immunohistochemical technique (PAP method), we analyzed the distribution ofTILs from 12 different patients with cancer of digestive tract and theexpression of CD3, CD4, CD8, CD25 and HLA - DR antigens on these lymphocytes in situ . The results showed : (1) TILs were mainly located in interstitium in tumor and rarely in parenchyma . (2) The main part in TIL was CD3+ T lymphocytes, and CDt cells were less than CD8+ones in both interstitium and parenchyma , but CD4+/CD8+ ratio in interstitium was higher than that in parenchyma .(3) There were TILs bearing CD25 or HLA - DR antigens in both inters titium and parenchyma in tumor tissues. As far as the possible mechanisms of these changes were also discussed in this article.更多还原