【摘要】 目的探讨ｎｍ２３Ｈ１基因与恶性及半恶性骨肿瘤相关性。方法以３０例骨肿瘤手术切除组织为标本，分别进行ｎｍ２３Ｈ１ｍＲＮＡ原位杂交及单克隆抗体的免疫组化研究。结果ｎｍ２３Ｈ１基因的表达在骨巨细胞瘤４例原发者中为阳性，３例复发者中为阴性；在８例骨肉瘤中６例阳性；在Ｅｗｉｎｇ瘤、恶性纤维组织细胞瘤及转移癌中表达基本为阴性；在４例软骨肉瘤中３例阴性。结论ｎｍ２３Ｈ１的表达可能与骨巨细胞瘤的复发有一定相关性，而在骨肉瘤的研究中未发现其相关性。更多还原

【Abstract】 Objective To explore the correlation between nm23H1 gene and malignant and semi-malignant bone tumors. Method Thirty surgical specimens were collected,including 8 osteosarcomas,7 giant cell tumors,4 chondrosarcomas,2 Ewings sarcomas,2 malignant fibrohistocytomas,1 neurofibrosarcoma,1 schwannoma,and 5 metastatic cancers.The expression of nm23H1 in these specimens was observed by in situ hybridization and immunohistochemical staining. Result The expression of nm23H1 in 4 cases of primary giant cell tumor (GCT) was high,but was low or absent in 3 recurrent ones.In 4 cases of chondrosarcomas, the expression was positive.Its expression was basically negative in Ewings tumor,malignant fibrous histiocytoma and metastatic sarcomas. Conclusion There is no association of nm23H1 with osteosarcoma.更多还原