【摘要】 目的探讨与感染有关的细胞因子(interleukin-1β,IL-1β)、(interleukin-6,IL-6)、(tu-mor necrosis factor-a,TNF-α)在早产中的应用。方法取30例早产孕妇和31例足月临产孕妇,46例足月未临产孕妇的血和羊水标本,分别行血 IL-6、羊水中 IL-1β、IL-6及 TNF-α和胎盘行病理检查。结果 (1)早产组的羊水中 IL-1β、IL一6、TNF-α及血浆中 IL-6水平显著高于妊娠足月组(包括临产组和未临产组)。早产组中有宫内感染孕妇的细胞因子水平显著高于无宫内感染者。(2)羊水和血浆中IL-6水平有明显的相关性。结论早产有宫内感染者血浆及羊水中细胞因子水平高于无宫内感染者,血浆 IL-6水平与羊水 IL-6水平密切相关。更多还原

【Abstract】 Objective To investigate the levels of interleukin-1β,interleukin-6,tumor necro- sis factor-α in preterm labor with intraamniotic infection(IAI).Methods Plasma and amniotic fluid were sampled from 30 women with preterm labor(Group A),31 women with term labor(Group B) and 46 women without labor but after 37 weeks(Group C).Interleukin-6 in blood,interleukin-1β, interleukin-6 and tumor necrosis factor-α in amniotic fluid were examined.IAI were diagnosed accord- ing to clinical criteria or bacterial culture or pathology.Results 1.The levels of IL-6 in blood in Group A were higher than in Group Band C(46.34 vs 20.53,6.67pg/ml,P<0.05).IL-1β,IL-6, TNF-α in amniotic fluid in Group A were higher than in Group B and C(IL-1β:292.63 vs 122.29, 43.20 pg/ml;IL-6:1721.56 vs 897.98,524.52;TNF-α:263.53 vs 97.49,38.10pg/ml,P<0.05).In Group A,the leves of cytokins were higher in the women with IAI than those without IAI.2.The level of IL-6 in plasma and amniotic fluid was well correlated(r=0.67).Conclusions The levels of cytokins in plasma and amniotic fluid were higher in preterm labor.In preterm labor,the levels of eytokins in women with IAI are higher than those without IAI.The levels of IL-6 in plasma and am- niotic fluid are correlated significantly.更多还原