【摘要】 目的探讨新生鼠缺氧缺血脑损伤后实施亚低温的最佳疗程和温度。方法实验性缺氧缺血损伤模型鼠(n=82)于损伤后分为三组:室温恢复组(n=22)由母鼠喂养;环境温度29℃或31℃两组动物(n=60)分别进行24小时、48小时和72小时的亚低温干预,此期间采用配方奶喂养,干预结束后仍由母鼠喂养,观察血糖、血气和病理变化以划断疗效。结果环境温度31℃或29℃可降低脑温3℃或5℃。血糖维持正常,病理结果发现亚低温干预可使脑损伤程度减少46%～86%。结论缺氧缺血后连续72小时降低脑温4～5℃能取得最佳的脑保护作用。更多还原

【Abstract】 Objective To investigate the optimal mild hypothermia course and cerebral temperature of the neonatal rats after hypoxic-ischemic brain injury. Methods The posthypoxic-ischemic rats of experimental group (n=60) were placed in the glass jars immeresd in water bath held constaut at either 29 C or 3l C for 24h, 48h or 72h. While the rats of room temperature group (n=22) were stayed in room air. Blood glucose, blood gases and neuropathology findings were studied to determine the therapeutic effects. Results The brain temperature droped 3C or 5C when enviro ment temperature was 31C or 29C respectively. The blood glucose remained normal. Neuropathology findings reveled that the brain damage of experimental rats reduced 46%～86% compared to the room temperature group. Conclusion Reducing the cerebral temperature by 4～5 C for 72 hours after hypoxic-ischemic brain injury can lead to superior protective effect.更多还原