【摘要】 目的应用不同剂量的重组人类促红细胞生成素（rhEpo）治疗早产儿贫血,以期探讨其最适剂量及疗效。方法 150U·kg^-1·t^-1和250U·kg^-1·t^-1,隔天1次,每周3次,皮下注射,分别治疗10例和15例胎龄35周以下,出生体重小于2000g 早产儿,并与15例同胎龄、同出生体重早产儿对照。结果 3组早产儿生后血红蛋白（Hb）、红细胞压积（Hct）均逐渐下降,但 rhEpo 750U·kg^-1·wk^-1组下降程度最轻,对照组下降程度最明显,经方差分析,3组之间差异有显著性（P 均<0.0001）;治疗后网织红细胞（Ret）较对照组明显升高（P 均<0.000 1）,但两治疗组之间无显著性差异;3组血清 Fe 生后均逐渐下降,治疗组第2周明显低于对照组,第4周更甚,与对照组比,差异有非常显著性（P均<0.01）,但两种不同剂量组之间差异不明显。治疗结束时,两治疗组血清 Fe 均上升,与对照组比,差异无显著性（P>0.05）;治疗后750U·kg^-1·wk^-1组血清 Epo 浓度高于450U·kg^-1·wk^-1组和对照组,经方差分析,差异有非常显著性（P 分别为<0,000 1,0.01,0.05）,但450U·kg^-1·wk^-1组与对照组差异无显著性。结论 rhEpo 可提高 Hb、Hct 及 Ret,并且疗效与剂量有关,较大剂量疗效更显著,可减少甚至替代输血需要,是治疗早产儿贫血的一个新里程碑。更多还原

【Abstract】 Objective To assess the efficacy and the optimum dose of recombinant human ery- thropoietin（rhEpo） in the treatment of the anemia of premature.Methods 40 preterm infants with less than 35 weeks of gestational age and less than 2000gin of birth weight were randomly assigned to receive subcutaneous rhEpo 150U·kg^-1·t^-1（n=10） 250U·kg^-1·t^-1（n=15）,three times weekly for 6 weeks,or no treatment（control,n=15）.Results Postnatal decline of hemoglobin（Hb） and hematocrit （Hct） were lessened in the treated groups,particularly in the rhEpo 250U·kg^-1·t^-1group; and there were significant differences in each groups by analysis of variance（all P<0.0001）.Treated infants had significantly higher reticulocyte counts （Ret）（all P<0.0001）,but there were not differ- ences beetwen the treated groups （P>0.05）.Serum iron dropped,more significantly in the treated groups than in control group （all P<0.01）,but there was no dose-dependent relationship in treated infants（P>0.05）.After treatment,serum levels of erythropoietin was higher in rhEpo 250U·kg^-1, t^-1 group than in both rhEpo 150U·kg^-1·t^-1 and control groups （P<0.0001,0.01,0.05, respectively）.There were no significant differences between the rhEpo 150U·kg^-1·t^-1 and control groups （P>0.05）.No side effects related to rhEpo therapy were observed.Conclusious RhEpo therapy for premature infants is effective and dose-dependent.Therapy is more efficient when given in high dose.It can reduce or replace the need for blood transfusion.更多还原