【摘要】 目的探讨CD44v6表达与大肠癌预后的关系。方法对156例大肠癌存档石蜡组织标本进行重新切片,采用CD44v6鼠单克隆抗体进行免疫组化染色(LSAB法)。结果 CD44v6表达与年龄、性别、肿瘤大小、部位、组织类型无关;CD44v6阳性表达率在Dukes C/D期较Dukes A、B期高,有肿瘤转移及术后复发者较无肿瘤转移和未复发者高;CD44v6表达阳性者术后生存率较表达阴性者低,Cox模型生存分析,CD44v6未能进入最终的回归方程。结论 CD44v6在大肠癌转移和复发中可能具有一定的作用,但尚不能作为预测大肠癌预后的独立的生物学指标。更多还原

【Abstract】 Objective To investigate the relationship between expression of CD44v6 gene and prognosis in col-orectal carcinoma (CC). Methods The paraffin-embedded sections from 156 patients with CC were test-ed by labeled streptavidin-biotin (LSAB) immunohistochemieal technique with anti-CD44v6 murine mono-clonal antibody (2F10). Results There was no significant correlation between the expression of CD44v6 gene and sex, age, size of tumor, tumor location or histological type. The positive staining of CD44v6 was stronger in Dukes C/D stages than in Dukes A and B stages. There were also stronger positive staining in those who had tumor metastasis and recurrence than those without tumor metastasis and recurrence. The patients with positive staining of CD44v6 had a lower postoperative survival rate than those with negative staining, but Cox regression analysis showed there was no significant correlation between expression of CD44v6 and prognosis in CC. Conclusion CD44v6 may play a role in metastasis and recurrence, but it may not be an independent biological prognostic indicator in CC.更多还原