【摘要】 目的：研究蛋白激酶Ｃ抑制剂Ｃｈｅｌｅｒｙｔｈｒｉｎｅ对大鼠脑缺血时纹体γ－氨基丁酸（ＧＡＢＡ）和甘氨酸（Ｇｌｙ）释放的影响。方法：用微透析和高压液相法测定大鼠半球缺血时纹体ＧＡＢＡ和Ｇｌｙ的释放。结果：脑缺血时纹体ＧＡＢＡ和Ｇｌｙ的释放明显升高。前者被Ｃｈｅｌｅｒｙｔｈｒｉｎｅ促进而后者则被抑制。结论：脑缺血时纹体ＧＡＢＡ和Ｇｌｙ释放的明显升高参与了脑缺血病理过程，蛋白激酶Ｃ抑制剂Ｃｈｅｌｅｒｙ－ｔｈｒｉｎｅ可能通过这一机制具有某些保护缺血大脑的作用更多还原

【Abstract】 Objective: To study the effects of PKC inhibitor chelerythrine on the releases of GABA and Gly from ischemic rat striatums. Methods: The releases of GABA and Gly from rat striatums during global ischemia were determined by microdialysis and HPLC methods. Results: Release of GABA and Gly from ischemic rat striatums were significantly increased. The former was promoted, however, the latter was inhibited by PKC inhibitor Chelerythine respectively. Inclusion: Oncreased releases of GABA and Gly are involved in the pathogeneses of brain ischemia and the PKC inhibitor chelerythrine may have some protective effects on cerebral ischemia through this mechanism.更多还原