【摘要】 目的探讨血小板源生长因子（PDGF）、转化生长因子-β₁（TGF-β₁）对伤口愈合的影响。方法用原位杂交技术观察人断层皮片供皮区创面愈合过程中内源性 PDGF、TGF-β₁的基因表达。结果发现人断层皮片供皮区创面愈合过程中内源性 PDGF、TGF-β₁的基因有明显表达。结论其表达规律性在创面愈合过程中可能起着重要的调控作用。更多还原

【Abstract】 Objective A series of studies has shown that exogenous growth factors could en- hance healing in different types of wounds.This study was to investigate endogenous changes in growth factors during the process of wound healing.Method In situ hybridization was used to examine the ex- pression of endogenous PDGF mRNA and TGF-β₁ mRNA in the process of wound healing of a split-skin graft donor site in human.Result The results demonstrated that there were obvious expressions of endogenous PDGF and TGF-β₁ during wound healing.Conclusion The regularity of its expression has close correlation with the time of wound healing,suggesting PDGF and TGF-β₁ might play key roles in wound healing.更多还原