【摘要】 目的　了解淋病奈瑟菌对抗生素敏感性的变迁情况。方法　对门诊 1991年和 1996年各 10 0株标本进行了 12种抗生素最小抑菌浓度 (MIC)测定。同时对产青霉素酶株 (PPNG)和非产青霉素酶株 (non PPNG)的MIC值进行了比较。结果与结论　青霉素G、四环素等 6种抗生素MIC值 1996年与 1991年两者之间有显著性差异 (P <0 0 5或P <0 0 1)。其中MIC50 值变化较大的是青霉素G和氟哌酸 ,1996年比 1991年均增加 6 3倍。此外 ,PPNG株和non PPNG株MIC值也存在差异更多还原

【Abstract】 Objective To study the changes of susceptibilities of Neisseria gonorrhoeae to antibiotics in Chengdu area. Methods The MIC values of 12 antibiotics to 100 strains in 1991 and 100 strains in 1996 were determined, and the MIC values to PPNG and non PPNG strains were also compared. Results and Conclusion The MIC values of 6 antibiotics (including penicillin G, tetracycline,etc.) to the isolates in different periods changed significantly (P<0.05 or P<0.01), and among them the values of MIC 50 of penicillin G and norfloxacin in 1996 had a 63 fold increase over those in 1991. Moreover, there was a difference in MIC values between PPNG and non PPNG strains.更多还原