【摘要】 试用不同除爆方法降低国产左旋炔诺孕酮硅胶（ＣＬＡ）皮下埋植棒的“爆破效应”，结果显示：经与９５％乙醇搅拌３０ｍｉｎ再置３７±０．５℃浸泡１５ｈ处理，具有良好除爆效果。皮下埋植棒体外２０ｄ释放量进口品ＮｏｒｐｌａｎｔＩ型为５７．６μｇ／ｄ，ＣＬＡ除爆前后分别为７３．３μｇ／ｄ和５２．３μｇ／ｄ，有显著差异（Ｐ＜０．０５）更多还原

【Abstract】 The domestic levonorgestrel (1)silastic capsule implants (CLA) was stirred with 95% ethanol for 30 min, then soaked with 95% ethanol at 37±0.5℃ for 15 h to lower their burst effect. The average daily released amounts of 1 measured within 20 d in vitro were 52.3 μg for CLA treated, 57.6 μg for imported Norplant I, and 73.3 μg for CLA untreated. There was obvious difference between CLAs after and before treatment更多还原