【摘要】 目的:观察复方丹参（SMC）对体外循环（CPB）下心肌缺血再灌注血清内皮素（ET）,血栓素（TXB₂）和6-keto—PGF_1α(PGF_1α)变化的。方法:20例先天性心脏病室缺（VSD）、房缺（ASD）修补患者随机分为对照组（组Ⅰ,10例）及复方丹参组（组Ⅱ,10例）。组Ⅱ于切皮前30分与复温时至心脏复跳前,分别静脉滴注SMC200mg/kg。组Ⅰ在同一时间给予等量平衡盐液。两组于术前（T₀）,CPB后5分（T₁）,心肌缺血30分（T₂）,再灌注后10分（T₃）、30分（T₄）,停CPB后30分（T₅）,术后24小时（T₆）,经中心静脉抽血样,分别测ET,PGF_1α和TXB₂浓度。结果:两组再灌注期血清ET较缺血期明显增加,组Ⅱ再灌注后T₄、T₅及T₆的ET值显著低于组Ⅰ（P<0.05）。再灌注后两组血清PGF_1α逐渐下降,而组Ⅰ的TXB₂呈上升趋势,组Ⅱ的TXB₂在T₄、T₅、T₆又下降,各期值显著低于组Ⅰ（P<0.01）。结论:SMC能显著降低再灌注期ET、TXB₂的产生,从而促进CPB后心功能的恢复。更多还原

【Abstract】 Objective: To observe the effects of salvia miltiorrhizae compound （SMC） on serum endothelin （ET）, TXB₂ and PGI₂ levels in patients undergoing CPB. Method: Twenty patients with congenital heart disease were randomly divided into control group （group Ⅰ） and treated group （group Ⅱ）. SMC （200mg/kg） were given intravenously in group Ⅱ before operation and during rewarming, in group Ⅰ eqivalent volumes of normal saline were administered at the same time point. The serum ET,TXB₂ and PGI₂ levels were measured at preoperation （T₀） 5min （T₁）, and 30min （T₂） following CPB, 10min （T₃）, 30min （T₄） and 60min （T₅） following reperfusion, 24h （T₆） after operation. Result: In both groups,the serum ET level were increased significantly during reperfusion, but much less in group Ⅱ than that in group Ⅰ at T₄, T₅ and T₆（P<0.05）. The serum PGI₂ of both groups were decreased continuously during reperfusion. The TXB₂ level was increased in group Ⅰ but decreased in group Ⅱ at T₄, T₅ and T₆. The postoperative cardiac function recovered much more better in group Ⅱ than in group Ⅰ. Conclusion: SMC can reduce dramatically the production of ET and TXB₂ during reperfusion to improve cardiac function recovery after CPB.更多还原