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诱导性一氧化氮合酶抑制药对感染性休克兔肠系膜微循环的影响

The effects of inducible nitric oxide synthase(iNOS)inhibitor on the microcirculation of the rabbits mesenterium in septic shock

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【作者】 宋冰冰王俊科盛卓人崔涌孙新艳

【Author】 Song Bingbing;Wang Junke;Sheng Zhuoren;et al;Department of Anesthesiology of the First Affiliated Hospital of China Medical University;Shenyang 110001

【机构】 中国医科大学第一临床学院麻醉科中国医科大学第一临床学院麻醉科 110001 沈阳市110001 沈阳市

【摘要】 目的:观察iNOS抑制药AG对感染性休克兔肠系膜微循环功能的影响。方法:大耳白兔输注LPS(300μg.kg~-1.h~-1)。MAP下降至基础的60%后2小时将受试动物随机分为L-NAME(30mg.kg~-1,n=6)和AG(20mg.kg~-1,n=6)2组。结果:MAP下降后2小时肠系膜微动静脉明显扩张。给予L-NAME后微动脉内径减少45%,比基础值减少15%(P<0.05);微静脉内径减少20%,但与基础无差异。给予AG后微动脉内径减少30%(P<0.05),而比基础值增加8%。L-NAME组微动脉明显细于AG组。给LPS后血流速度明显减慢。L-NAME使之进一步减慢,而AG对流速有一定改善。结论:AG对肠系膜血管内径和血流速度影响小,可在一定程度上改善感染性休克兔的微循环。

【Abstract】 Objective: To investigate the effects of AG, an iNOS inhibitor on microcirculation of the septic shock rabbits. Method: The white rabbits were infused endotoxin(LPS, 300μg. kg-1in lh. Two hours after the MAP de creased to 60% of the baseline, the rabbits were grouped randomly as L-NAME(n=6.30 mg. kg-1)I. V. group and AG(n=6,20 mg. kg-1) I. V. group. Result: Two hours after MAP decreased, the blood velocity decreased, the arterio lar of mesenterium dilated by 18%(P<0.05) the venula dilated only by 7%(P<0.05). After injection of L-NAME. the arteriolar constricted by 15% compared with baseline, by 45% compared with pretreatment, the diameter of venula was 20% less than pretreatment, not less than baseline. The velocity continued to decrease. After injection of AG, the arteriolar constricted by 30%, but still dilated by 8% compared with baseline, the velocity improved. Conclusion: AG has little effects on the arteriolar and blood velocity, can improve the mesenterium microcirculation of the rabbits in septic shock to some extent.

【关键词】 微循环休克,感染性氨基胍
【Key words】 MicrocirculationShocksepticAminoguanidine
【基金】 1996年卫生部科学基金资助
  • 【文献出处】 中华麻醉学杂志 ,Chinese Journal of Anesthesiology , 编辑部邮箱 ,1998年05期
  • 【分类号】R96
  • 【被引频次】3
  • 【下载频次】39
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