节点文献
诱导性一氧化氮合酶抑制药对感染性休克兔肠系膜微循环的影响
The effects of inducible nitric oxide synthase(iNOS)inhibitor on the microcirculation of the rabbits mesenterium in septic shock
【摘要】 目的:观察iNOS抑制药AG对感染性休克兔肠系膜微循环功能的影响。方法:大耳白兔输注LPS(300μg.kg~-1.h~-1)。MAP下降至基础的60%后2小时将受试动物随机分为L-NAME(30mg.kg~-1,n=6)和AG(20mg.kg~-1,n=6)2组。结果:MAP下降后2小时肠系膜微动静脉明显扩张。给予L-NAME后微动脉内径减少45%,比基础值减少15%(P<0.05);微静脉内径减少20%,但与基础无差异。给予AG后微动脉内径减少30%(P<0.05),而比基础值增加8%。L-NAME组微动脉明显细于AG组。给LPS后血流速度明显减慢。L-NAME使之进一步减慢,而AG对流速有一定改善。结论:AG对肠系膜血管内径和血流速度影响小,可在一定程度上改善感染性休克兔的微循环。
【Abstract】 Objective: To investigate the effects of AG, an iNOS inhibitor on microcirculation of the septic shock rabbits. Method: The white rabbits were infused endotoxin(LPS, 300μg. kg-1in lh. Two hours after the MAP de creased to 60% of the baseline, the rabbits were grouped randomly as L-NAME(n=6.30 mg. kg-1)I. V. group and AG(n=6,20 mg. kg-1) I. V. group. Result: Two hours after MAP decreased, the blood velocity decreased, the arterio lar of mesenterium dilated by 18%(P<0.05) the venula dilated only by 7%(P<0.05). After injection of L-NAME. the arteriolar constricted by 15% compared with baseline, by 45% compared with pretreatment, the diameter of venula was 20% less than pretreatment, not less than baseline. The velocity continued to decrease. After injection of AG, the arteriolar constricted by 30%, but still dilated by 8% compared with baseline, the velocity improved. Conclusion: AG has little effects on the arteriolar and blood velocity, can improve the mesenterium microcirculation of the rabbits in septic shock to some extent.
- 【文献出处】 中华麻醉学杂志 ,Chinese Journal of Anesthesiology , 编辑部邮箱 ,1998年05期
- 【分类号】R96
- 【被引频次】3
- 【下载频次】39