【摘要】 目的:观察iNOS抑制药AG对感染性休克兔肠系膜微循环功能的影响。方法:大耳白兔输注LPS(300μg.kg~-1.h~-1)。MAP下降至基础的60%后2小时将受试动物随机分为L-NAME(30mg.kg~-1,n=6)和AG(20mg.kg~-1,n=6)2组。结果:MAP下降后2小时肠系膜微动静脉明显扩张。给予L-NAME后微动脉内径减少45%,比基础值减少15%(P<0.05);微静脉内径减少20%,但与基础无差异。给予AG后微动脉内径减少30%(P<0.05),而比基础值增加8%。L-NAME组微动脉明显细于AG组。给LPS后血流速度明显减慢。L-NAME使之进一步减慢,而AG对流速有一定改善。结论:AG对肠系膜血管内径和血流速度影响小,可在一定程度上改善感染性休克兔的微循环。更多还原

【Abstract】 Objective: To investigate the effects of AG, an iNOS inhibitor on microcirculation of the septic shock rabbits. Method: The white rabbits were infused endotoxin(LPS, 300μg. kg^-1in lh. Two hours after the MAP de creased to 60% of the baseline, the rabbits were grouped randomly as L-NAME(n=6.30 mg. kg^-1)I. V. group and AG(n=6,20 mg. kg^-1) I. V. group. Result: Two hours after MAP decreased, the blood velocity decreased, the arterio lar of mesenterium dilated by 18%（P<0.05） the venula dilated only by 7%（P<0.05）. After injection of L-NAME. the arteriolar constricted by 15% compared with baseline, by 45% compared with pretreatment, the diameter of venula was 20% less than pretreatment, not less than baseline. The velocity continued to decrease. After injection of AG, the arteriolar constricted by 30%, but still dilated by 8% compared with baseline, the velocity improved. Conclusion: AG has little effects on the arteriolar and blood velocity, can improve the mesenterium microcirculation of the rabbits in septic shock to some extent.更多还原