【摘要】 目的探讨精神分裂症可能的发病和衰退机理。方法利用日立８３５型快速氨基酸分析仪，测定和分析３０例住院精神分裂症患者（急性１５例，慢性１５例）的血浆谷氨酸（Ｇｌｕ）、牛磺酸（Ｔａｕ）、γ氨基丁酸（ＧＡＢＡ）、甘氨酸（Ｇｌｙ）的含量变化，并与对照组（健康志愿者１０例）比较。结果（１）血浆Ｇｌｕ和ＧＡＢＡ含量患者组（８３±２４μｍｏｌ／Ｌ，５６±１７μｍｏｌ／Ｌ）显著低于对照组（１２６±５７μｍｏｌ／Ｌ，９０±１７μｍｏｌ／Ｌ），而血浆Ｔａｕ和Ｇｌｙ含量两组间差异无显著性；（２）慢性患者的血浆Ｇｌｕ和ＧＡＢＡ含量（９３±３１μｍｏｌ／Ｌ，６６±２２μｍｏｌ／Ｌ）高于急性患者（６９±１９μｍｏｌ／Ｌ，４９±１１μｍｏｌ／Ｌ），存在随病程迁延而增高的趋势；（３）３０例患者血浆ＧＡＢＡ的含量与阴性症状（ｒ＝０．４７０，Ｐ＜０．０１）和社会功能缺陷（ｒ＝－０．５６７，Ｐ＜０．０１）的严重程度呈显著性相关。结论精神分裂症可能与Ｇｌｕ能和ＧＡＢＡ能神经系统功能低下有关。中枢神经系统Ｇｌｕ和ＧＡＢＡ严重的功能失调可能导致精神分裂症慢性衰退的结局。更多还原

【Abstract】 Objective To explore the mechanism of pathogenesis and deterioration of schizophrenia. Methods Plasma levels of glutamic acid (Glu), taurine (Tau), GABA and glycine (Gly) were determined with Hitachi model 835 high speed amino acid analyzer in 30 schizophrenic inpatients (15 acute and 15 chronic) and 10 controls. Results 1. Plasma Glu and GABA levels were significantly lower in the schizophrenics than that in controls, but no difference in plasma Tau and Gly levels; 2. Plasma Glu and GABA levels were significantly higher in patients with chronic and defect state than those in acute episodic phase. It seems to be an increasing trend of plasma Glu and GABA levels in schizophrenics with prolonged course; 3. In the 30 schizophrenics, plasma GABA level was significantly correlated to the severity of negative symptoms and impairment of social functioning. Conclusion These findings suggest that glutamatergic and GABAnergic deficit in central nervous system may be involved in the pathophysiology of schizophrenia. The severe dysfunction of GABA and Glu in central nervous system may lead to chronic deterioration in schizophrenia.更多还原