【摘要】 目的探讨急性坏死性胰腺炎（ＡＮＰ）对肺损伤影响的作用机制。方法用３．５％牛磺胆酸经胰胆管逆行注射建立ＡＮＰ模型，观察血清炎性细胞因子和介质的变化及肺损伤的病理改变。结果ＡＮＰ可引起炎性细胞因子ＩＬ－１β、ＩＬ－６，ＴＮＦα和炎性介质ＰＬＡ２、淀粉酶升高，也可引起血中和肺组织内ＴＮＦα，ＩＬ－１β的过度表达及肺部严重受损。用生长抑素治疗后，炎性细胞因子和介质明显下降和肺组织受损减轻。结论ＡＮＰ造成肺损伤与炎性细胞因子过度释放和参与有关。更多还原

【Abstract】 Objective To study the pathogenesis of lung injury in acute necrotizing pancreatitis(ANP). Method Retrograde pancreatic-injection of 3.5 % sodium tuarocholate in rats was used to prepare ANP model and examine the pathology of lung injury. Results Following sodium taurocholate injection, there were remarkable elevation of serum IL-1β, IL-6,TNFα PLA2, amylase and pulmonary IL-1β, TNF-α, associated with severe lung damage. The cytokines, amylase and PLA2 levels were decreased by somatostatin (Stilamin) treatment concomitant with amelioration of various pulmonary pathology . Conclusion The present study revealed the increase of various inflammatory cytokines were related with the productions of lung inj ury in ANP.更多还原