【摘要】 目的研究重度妊高征（ＰＩＨ）患者肝脏Ｂ超和病理变化，探讨其与妊娠脂肪肝的关系。方法将９０例晚期妊娠妇女分为３组，妊娠合并肝病组、轻中度ＰＩＨ组及重度ＰＩＨ组各３０例。入院后进行肝脏Ｂ超检查。重度ＰＩＨ组有１５例在Ｂ超引导下行肝穿刺，组织行苏丹Ⅲ染色及ＨＥ染色，在光镜下检查脂肪浸润情况。结果妊娠合并肝病组及重度ＰＩＨ组，分别有２例及１２例Ｂ超提示脂肪肝。１５例重度ＰＩＨ肝穿病理中，有１４例显示不同程度的脂肪浸润，其中有８例Ｂ超提示为脂肪肝。结论肝脏脂肪浸润是ＰＩＨ肝脏受损广泛的病理变化之一，可能与妊娠急性脂肪肝存在相关的发病机理更多还原

【Abstract】 Objective To investigate the liver changes in severe pregnancy induced hypertension (PIH) on Bultrasound and pathological examination and to detect a possible connection with fatty liver of pregnancy. Methods From Jan 1992 to Nov 1997, 90 pregnant women in the third trimester were enrolled for study. They were divided into 3 groups: the pregnant women with liver diseases; mild and moderate PIH; and severe PIH (30 cases each ). Ultrasonography of the liver was performed on each patient after admission. 15 percutaneous liver biopsies were performed under the guidance of realtime ultrasound scans on 15 severe PIH patients with or without liver dysfunction. Tissues were stained with specific lipid staining (Sudan) and with hematoxylineosin. All specimens were analyzed by light microscopy. Results Fatty liver was observed by Bultrasound in 2 and 12 cases of the pregnancy with liver diseases group and the severe PIH group, respectively. 14 of the 15 liver biopsy specimens showed fatty infiltration of varying degrees. however, only 8 of the 14 cases were detected fatty liver by Bultrasound. Conclusions These findings suggest that liver involvement in severe PIH is a pathological change. Severe PIH and acute fatty liver in pregnancy could have related pathogenesis components of the same.更多还原