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心肌疾病抗ADP/ATP载体抗体与粒细胞-巨噬细胞集落刺激因子的临床研究

A clinical study of autoantibody against myocardiac adenine nucleotide translocator and granulocyte macrophage colony stimulating factor in children with myocardiac diseases

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【作者】 徐灵敏安金斗刘松茂石曼君高铁铮

【Author】 Xu Lingmin, An Jindou, Liu Songmao, et al. Department of Pediatrics, The First Affiliated Hospital, Henan Medical University, Zhengzhou 450052

【机构】 河南医科大学第一附属医院儿内科

【摘要】 目的探讨病毒性心肌炎(VMC)和扩张型心肌病(DCM)的自身免疫发病机制。方法采用免疫印转和放射免疫技术检测了30例VMC、14例DCM患儿血浆中抗心肌线粒体ADP/ATP运载蛋白(ANT)抗体和粒细胞-巨噬细胞集落刺激因子(GM-CSF)。结果VMC和DCM患儿抗ANT抗体和GM-CSF的阳性率分别为73%和57%,而25例正常健康儿分别为0和12%(P均<0.01),且抗ANT抗体与GM-CSF的血浆水平呈正相关(r=0.4091,P<0.05)。结论小儿VMC和DCM的发病与心肌的自身免疫损伤有关,抗ANT抗体和GM-CSF均参与了这一过程。抗ANT抗体可作为小儿VMC和DCM的一种特异性诊断指标。

【Abstract】 Objective To explore the autoimmune pathogenic mechanisms responsible for viral myocarditis (VMC) and dilated cardiomyopathy (DCM). Methods The plasma autoantibody against myocardiac adenine nucleotide translocator (ANT) and granulocyte macrophage colony stimulating factor (GM CSF) in children (30 with VMC, 14 with DCM) were studied with western blot and radioimmunoassay. Results The plasma levels of anti ANT and GM CSF in patients of VMC and DCM groups were significantly higher than those in the healthy group (73% vs 0 for anti ANT, P <0.01; 57% vs 12% for GM CSF, P <0.01), and there was a significant correlation between the plasma levels of anti ANT and GM CSF ( r =0.4091, P <0.05). Conclusion Anti ANT and GM CSF both participate in the pathogenesis of VMC and DCM, and they are involved in the process of autoimmune injury of myocardium. Anti ANT can be taken as a specific marker for diagnosis of VMC and DCM in children.

  • 【文献出处】 中华儿科杂志 ,Chinexe Journal of Pediatrics , 编辑部邮箱 ,1998年05期
  • 【分类号】R542.2
  • 【被引频次】18
  • 【下载频次】46
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