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引种栽培瓦布贝母、浓蜜贝母与野生川松贝母的药理作用比较研究

Comparison of Pharmacological Effects Between Cultispecies Sichuan Fritillary Bulb(F.wabueasis,F.mellea)and Wild Sichuan Fritillary Bulb(F.unibracteata)

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【作者】 莫正纪唐心曜孙中李玮

【Author】 Mo Zhengji,Tang Xinyao,Sun Zhong and Li Wei (School of Pharmacy,West China University of Medical Sciences,Chengdu 610041)

【机构】 华西医科大学药学院

【摘要】 栽培川贝母(瓦布贝母、浓蜜贝母)在小鼠镇咳、大鼠祛痰、小鼠常压耐缺氧、小鼠离体肺脏支气管灌流的药理作用及小鼠口服毒性方面与野生暗紫贝母完全相同,而在升高小鼠肺脏cAMP水平及豚鼠平喘作用方面,栽培瓦布贝母的作用明显优于野生暗紫贝母。

【Abstract】 The ethanol extracts from the cultured Sichuan Fritillary bulb have been proved similar to those from the wild one in treating coughing in mice,expectoration in rats,asthma in guinea pigs,bronchodilation of isolated lungs in mice,and cyclic nucleotide(cAMP,cGMP)in the plasma and lungs of mice.The acute toxicity of the cultured and wild species is also similar to each other.However,in terms of asthma relieving and cAMP level increment in the lungs,the cultured species F.wabueasis is significantly superior to the wild species of Fritillary bulb.

  • 【文献出处】 中国中药杂志 ,CHINA JOURNAL OF CHINESE MATERIA MEDICA , 编辑部邮箱 ,1998年01期
  • 【分类号】R285.5
  • 【被引频次】44
  • 【下载频次】382
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