【摘要】 目的：探讨影响鼻咽癌放疗后放射性脑病发生的有关因素。材料与方法：1987年至1996年共收治鼻咽癌1563例，发生放射性脑病31例。结果：放射性脑病的发生与性别，年龄无关，再程放疗与，程放疗比较分别为6．3％及1．3％（P＜0．01）；颅底骨质有、无破坏者发生率为4．6％及0．6％（P＜0．01）；T3、T4期患者与T1、T2期比较，分别为1．9％及0．6％（P＜0．05）；鼻咽部剂量≤65Gy者为0．6％，＞65Gy为2．4％（P＜0．05）；耳前野上界＞1．5cm者为2．2％，位于1．5cm者为0．7％（P＜0．05）。结论：放射性脑病的发生不仅有血管一神经性因素，脑组织的某些生化及免疫方面的改变，也是一个重要的因素。更多还原

【Abstract】 ? Objectives To investigate the etiologic factors of RE following radiation therapy for NPC. Materials and Methods: From 1987 to 1996, 1563 patients with NPC were radiotherapy. Among them, 31 cases developed RE. Results: The etiologic factors of RE don’t influenced the sex and age. Between repeated and definitive radiotherapy, the incidence of RE were 6. 3%and 1. 3 % respectively (P<0.01); Having and not having bone destractions of the skull base, were 4. 6% and 0. 6%respectively (P < 0.01 ); T3-4and T1-2lesions were 1. 9% and 0. 6% (P < 0. 05); The dose of naeopharyngeal ≤65Gy and > 65Gy, were 0. 6%and 2. 4% (P<0. 05); The upside of pre-auricalar portals= 1. 5cm and > 1. 5cm were 0. 7%and 2. 2 % (P<0. 05). Conclusion: The etiologic factors of RE are not only connected with the Vessel--Neural factors, but also has connected with some biochemical and immune factors on brain tissue. 〔更多还原