【摘要】 目的探讨胸腔内准注化疗治疗癌性胸水的临床效果。方法对56例癌性胸水患者（其中原发肿瘤为肺癌32例,乳癌17例,胃癌3例,大肠癌2例,恶性胸膜间皮瘤2例采用针吸法和胸腔内置管引流法使恶性胸水大部分排出。胸腔内注入化疗药：DDP70—100mg,ADM50-70mg,MMC15-20mg,5-Fu1000-1500mg。结果本组总有效率96.4％。随访时间均超过12个月。胸水缓解期超过6个月以上者为73.2％（41／56）。毒性反应食欲减退、恶心、呕吐者占72％,白细胞、血小板降低者19.8％。结论胸腔内灌注化疗治疗癌性胸水具有疗效好、毒性低、费用少、是值得推广的治疗方法。更多还原

【Abstract】 Objective To analyze the treatment results of malignant pleural effusions by pleural infusion chemotherapy. Methods Malignant pleural effusions were drained in 56 patients with 32 lung cancer, 17 breast cancer, 3 gastric cancer, 2 colorectal cancer, 2 pleural mesothelioma by the methods of needle aspiration and drainage tube in the pleural cavity. In pleural cavity,the chemotherapeutic agent (such as DDP 70- 100mg,ADM 50- 70mg,MMC 16-20mg, 5-Fu 1000- 1500mg) was used. Results An overall response rate of 96. 4% was yielded. The time of follow-up was Twelve months. Complete remission in six months was 73. 2% (41/56). The patients with loss of appetite, nausea and vomiting were 7. 2 % (41/56 ). Leukocytepenia and thrombocythemia were 19. 8 % (11/56). Conclusions The pleural infusion chemotherapy is an useful and effective methods of treatment in the patients with malignant pleural effusions.更多还原