【摘要】 应用图像分析技术，对18例小肝癌和38例大肝癌行DNA含量测定，并分析其肿瘤生物学特性，结果显示小肝癌DNA含量以低倍异倍体为主（66．7％），大肝癌以高倍异倍体为主（94．7％），P<0．01，在肿瘤包膜突破和癌栓形成率上小肝癌（11．1％和22．2％）明显低于大肝癌（P<0．01），小肝癌存在明显的不典型增生，预后优于大肝癌，而病理分级，肝硬变程度两组无显著差异。提示＜3cm的小肝癌基本反映了早期肝癌的肿瘤生物学特征，是获得根治性切除的良好时机。DNA含量测定是估计肝癌恶性程度和临床预后的准确和客观的指标。更多还原

【Abstract】 DNA content was quantitatively determined in 18 small hepatocellular carcinoma(small HCC) and 38 large HCC by image analysis technique. The result showed that low aneuploidDNA content were found in 66.7% of small HCC and high aneuploid were found in 94.7% of largeHCC (p<0.01). The incidences of tumor capsule invasion and cancerous thrombus formation were11. 1 % and 22. 2 % in small HCC which were significantly lower than in large HCC (p<0.01 ). Hepatocellular dysplasia was more evident in small HCC. The prognosis was better in small HCC. It issuggested that <3cm small HCC basically reflects the tumor biological characteristic of early HCCand is an important opportunity for achieving radical resection. The quantitatively analysis of DNAcontent is a precise and objective reference for evaluating tumor biologic feature and prognosis ofHCC.更多还原