【摘要】 目的：动态观察了乙醇摄入对口服磺胺嘧啶在小鼠体内过程及生物利用度的影响。方法：灌胃（ｉｇ）给予２．５ｇ·ｋｇ－１乙醇，一天一次，分别于２，４，６，８周静脉注射磺胺嘧啶４００ｍｇ·ｋｇ－１，２ｄ后灌胃给于同等剂量磺胺嘧啶，比色法测定血浓，３Ｐ８７药物动力学软件计算ＡＵＣｉｖ、Ｔ１／２βｉｖ、ＡＵＣｉｇ、Ｔ１／２βｉｇ、Ｔｍａｘ、Ｃｍａｘ。结果：２至４周，磺胺嘧啶在小鼠体内的ＡＵＣｉｇ、Ｔ１／２βｉｇ、Ｔｍａｘ、Ｃｍａｘ明显减少，６周后，ＡＵＣｉｇ、Ｔ１／２βｉｇ、Ｔｍａｘ、Ｃｍａｘ及生物利用度均明显增加，８周后与乙醇摄入６周相比，ＡＵＣｉｇ、Ｔ１／２βｉｇ明显增加，Ｔｍａｘ明显延长，Ｃｍａｘ及生物利用度则下降。结论：乙醇摄入可明显影响磺胺嘧啶的体内过程及生物利用度，其影响程度和方法取决于乙醇摄入时间和量更多还原

【Abstract】 OBJECTIVES: Influence of ethanol on pharmacokinetics and bioavailability of ig sulfadiazine (SD) in mice were studied. METHOD: ig 2.5 g·kg -1 ethanol was performed, one time per day, and iv 400 mg·kg -1 SD was operated at the second forth sixth eighth week respectively, after one day, ig 400 mg·kg -1 SD was operated at the same week, SD blood concentrations were determined by colorimetry, AUC iv T 1/2β iv AUC ig T 1/2β ig T max C max and bioavailability were calculated by 3P87 software of pharmacokinetics. RESULTS: In 2 weeks of the ethanol taken, AUC ig T 1/2β ig T max C max were reduced obviously, after 6 weeks AUC ig T 1/2β ig T max C max and bioavailability were increased obviously, but, at the eighth week, some different trends appeared, C max and bioavailability began to reduced. CONCLUSION: Influence of ethanol on pharmacokinetics and bioavailability of ig sulfadiazine in mice is obvious.更多还原