【摘要】 目的：研究Ｐ５３基因状况与抗癌化疗敏感性的关系，对抗癌药耐药机制进行探讨。方法：用ＭＴＴ法测定１７种抗癌药对８６例恶性肿瘤的抑制率，并用聚合酶链反应———单链构象多态分析技术检测其Ｐ５３基因状况。结果：统计比较抗癌药在Ｐ５３基因正常组和Ｐ５３基因异常组中的抑制率，发现多数抗癌药抑制率前者显著地大于后者。结论：当恶性肿瘤中存在Ｐ５３基因突变或缺失时，抗癌药耐药性显著增加。更多还原

【Abstract】 OBJECTIVE: To testify the relationship between the P53 gene status and chemosensitivity and explore the mechanism of antitumor drug’s resistance. METHOD: Using MTT method, we tested the inhibition rates of 17 antitumor drugs in 86 cancer patients, and also analysed the P53 gene status with polymerase chain reactionsingle stranded conformation polymorphism in it. RESULTS: The inhibition rates of majority antitumor drugs in the P53 gene normal group were significantly higher than in the P53 gene abnormal group. CONCLUSION: When the deletion and mutation of P53 gene occurred in the malignant tumours, the antitumor drugs’ resistance increased significantly.更多还原