【摘要】 目的：检测异丙酚（ＰＦ）对大鼠体循环与肺循环系统的影响。方法：应用电生理装置记录麻醉大鼠主动脉平均压（ＭＡＰ）、心率（ＨＲ）及肺动脉平均压（ＭＰＡＰ）在给与ＰＦ前后的变化。结果：ＰＦ４．０ｍｇ／ｋｇ静注可使基础状态时的ＭＡＰ、ＨＲ及ＭＰＡＰ降低。其中ＰＦ静注后３ｍｉｎ时，降低ＭＡＰ、ＨＲ作用最强，５ｍｉｎ时降低ＭＰＡＰ作用最强，且降低ＭＡＰ、ＨＲ作用明显强于降低ＭＰＡＰ作用。异丙酚还显著降低１．０ｍｇ／ｋｇ去甲肾上腺素和１００ｍｇ／ｋｇ５－羟色胺升高的ＭＡＰ、ＨＲ和ＭＰＡＰ，以降低ＭＡＰ、ＨＲ作用显著。结论：ＰＦ具有抑制循环系统作用，且以抑制体循环作用明显。提示其可能作用机理与降低对血管活性物质的反应性及松弛血管平滑肌相关。更多还原

【Abstract】 Objective:This paper was to study the effects of propofol on systemic and pulmonary circulation in rats. Methods:Using electronic physiological apparatus, we examined the changes of mean aortic pressure (MAP)、mean pulmonary arterial pressure(MPAP)and heart rate(HR) in anesthetized rats. Results:MAP,HR,and MPAP in basal condition bolus decreased after intravenous injection of 4.0 mg/kg propofol. The effect of propofol on decreasing MAP and HR in basal condition was most evident after three minutes of injection. The effect on decreasing MPAP was the strongest in 5 min. The effect of decreasing MAP and HR was apparently stronger than that of decreasing MPAP. Propofol significantly decreased MAP,HR,and MPAP which had been increased by 1.0 mg/kg norepinephrine and 100 mg/kg 5 hydroxytryptamine. Its effect on MPAP and HR were remarkable. Conclusions:Propofol exerted inhibitive effect on circulatory system,mainly on systemic circulation. The mechanism might be related to the decreasing of reactivity to vasoexcitor material and to the relaxation of vascular smooth muscle.更多还原