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四氢香叶醇的酯类衍生物合成及其透皮促进作用
Synthesis and Penetration of Tetrahydrogeraniol Derivatives
【摘要】 以四氢香叶醇(3,7-二甲基-1-辛醇)为原料,经酯化、相转移催化反应合成了丙酸四氢香叶醇酯及四氢香叶基硫烷基乙酸乙酯,并考察了它们对5-氟尿嘧啶的透皮促进作用
【Abstract】 Two derivatives were prepared from tetrahydrogeraniol via esterification and PCT reaction respectively They are 3,7dimethyloctyl propionate, ethyl3,7dimethyloctylthioacetateWe evaluated them as penetration enhancer toward 5flourouracil
【关键词】 四氢香叶醇;
丙酸四氢香叶醇酯;
四氢香叶基硫烷基乙酸乙酯;
透皮促进作用;
【Key words】 Tetrahydrogeraniol (3,7dimethyl1octanol); 3,7Dimethyloctyl propionate; Ethyl3,7dimethyloctylthioacetate; Penetration enhances;
【Key words】 Tetrahydrogeraniol (3,7dimethyl1octanol); 3,7Dimethyloctyl propionate; Ethyl3,7dimethyloctylthioacetate; Penetration enhances;
【基金】 国家自然科学基金
- 【文献出处】 中国药科大学学报 ,JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY , 编辑部邮箱 ,1998年02期
- 【分类号】TQ460.31
- 【被引频次】16
- 【下载频次】145