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酸性染料比色法测定愈美颗粒剂中氢溴酸右美沙芬的含量

Determination of Dextromethorphan Hydrobromide Contained in Yumei Granules by Acid Dye Colorimetry

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【作者】 樊夏雷陆兴周炜

【Author】 Fan Xialei; Lu Xin; Zhou Wei (Jiangsu Institute of Drug Quality Control, Nanjing 210008; Capital Airport Hospital, Beijing 100621;Pharmaceutical Analysis Department, China Pharmaceutical Unviersity, Nanjiny 210009)

【机构】 江苏省药品检验所!南京210008首都机场医院!北京100621中国药科大学药物分析教研室!南京210009

【摘要】 以溴麝香草酚蓝为酸性染料,在pH4.2时与氢溴酸右美沙芬形成有色的络合物,用氯仿提取后,在432nm处由比色法测定了愈美颗粒剂中氢溴酸右美沙芬的含量。方法简便、灵敏、准确,重现性好,模拟处方回收率为99.94/。

【Abstract】 An acid dye colorimetry method was described for the determination of dextromethorphan hydrobromide contained in Yumei Granules. Bromothymol blue as an acid dye combined with dextromethorphan hydrobromide at pH 4. 2 to form a colorful complex. With chloroform, the complex could be extracted, and the absorbance was measured at 432 nm. This method was simple, sensitive, accurate, specific and precise. The average recovery was 99. 94%.

  • 【文献出处】 中国药科大学学报 ,JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY , 编辑部邮箱 ,1998年06期
  • 【分类号】R927
  • 【被引频次】1
  • 【下载频次】35
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